Prognosis is a medical term for predicting the likely or expected development of a disease, including whether the signs and symptoms will improve or worsen or remain stable over time; expectations of quality of life, such as the ability to carry out daily activities; the potential for complications and associated health issues; and the likelihood of survival. A prognosis is made on the basis of the normal course of the diagnosed disease, the individual's physical and mental condition, the available treatments, and additional factors. A complete prognosis includes the expected duration, function, and description of the course of the disease, such as progressive decline, intermittent crisis, or sudden, unpredictable crisis.

किसी चिकित्सक द्वारा किसी रोगी के रोग की भविष्य की स्थिति के बारे में किये गये प्रागुक्ति (prediction) को चिकित्साशास्त्र की भाषा में प्राग्ज्ञान या पूर्वानुमान कहते हैं। यह एक प्रकार का चिकित्सीय निर्णय है। रोगों से सम्बन्धित सांखिकीय आंकडों के आधार पर प्राग्ज्ञा की जाती है।