Lesser, from Eliezer, is a surname. Notable people with the surname include:

• Adolf Lesser (1851–1926), German physician
• Aleksander Lesser (1814–1884), Polish painter and art critic
• Anton Lesser, British actor
• Axel Lesser, East German cross country skier
• Edmund Lesser (1852–1918), German dermatologist
• Erik Lesser, German biathlete
• Friedrich Christian Lesser (1692–1754), German theologian
• Gabriele Lesser, German historian and journalist
• George Lesser, American musician
• Gerald S. Lesser (1926–2010), American psychologist
• Henry Lesser, German footballer
• J Lesser, American musician
• Len Lesser (1922–2011), American actor
• Louis Lesser (1916–2013), American real estate developer
• Matt Lesser, Connecticut politician
• Mike Lesser (1943–2015), British mathematical philosopher and political activist
• Milton Lesser or Stephen Marlowe (1928–2008), American author
• Norman Lesser (1902–1985), Anglican bishop and Archbishop of New Zealand
• Otto Lesser (1830–1887), German astronomer
• Rika Lesser, American poet
• Robert Lesser, American actor
• Rosa Lesser, Austrian luger
• Ryan Lesser, Rhode Island video game designer
• Sam Lesser or Sam Russell (1915–2010), British journalist and Spanish Civil War veteran
• Sol Lesser (1890–1980), American film producer
• Stephen A. Lesser, American architect
• Virginia Lesser, American statistician
• Wendy Lesser, American author, editor and critic
• Werner Lesser (1932–2005), East German ski jumper